The story opens at the climax of a classic gothic horror story as intrepid vampire hunters Hans Von Illsbrook, his daughter Alana and their assistants infiltrate the castle of the murderous Lady Scarlet Dragunov. She is a monstrous vampire who stalks the remote villages of Romania and feeds on the terrified populace. Scarlet evades her pursuers and desperately flees to the New World.

But, her charted ship never arrives.

A band of vicious pirates, led by the white-haired Captain Frost seizes the vessel - taking everything, including Scarlet's coffin. When she awakens aboard the pirate vessel, her fury is merciless and quick. She wrests control of Frost's ship after feeding on his pirate crew and converts many others into her vampire servants. But, food is not all she wants. Scarlet has decided being in the New World, she can establish herself in a position of power.

Knowing she will cause misery and death wherever she goes, Illsbrook charters his own ship to hunt the creature, who now preys on island settlements and innocent passing ships with her crew of beastly vampires. Scarlet soon enlists more pirates to lay siege to a Spanish colony. Once conquered, she makes it her new home from which to set her minions loose on the Caribbean. Attacked by Scarlet's crew, the hunters are rescued by a Spanish warship. The ship was sailing to free the colony, but they do not heed warnings of what awaits.

Soon, the Spaniards are fighting for their lives as the pirates and vampires attack. Working together, the hunters and the Spanish captain devise a plan for freeing the colony and rescuing her kidnapped father. But, it will take more than a warship to stop the unholy creatures that stalk the islands. As they fight to free the colonists, Alana realizes the possibility that she may have to kill her own father to stop the vampires.

In the final confrontation, the hunters must overcome Scarlet and her minions before she can once again escape and threaten the entire Caribbean.